Grey's Anatomy Season 4, Episode 4 : The Heart of the Matter

Grey's Anatomy Season 4, Episode 4 : The Heart of the Matter

Meredith is seriously annoyed by Lexie's advances, when she desperately tries to keep in touch with her sister and to get to know her. Derek and Meredith's relationship just might be over, and Callie's marriage to George is put to the test. Guest Stars: Loretta Devine, Ron Melendez, Jeremy Rabb, Maile Flanagan, Gloria Garayua, Richard Keith, Edward Herrmann, Maggie Siff, Matt Lanter, Camille Winbush, Miriam Flynn, Nicole Rubio, Molly Kidder, Winston Story, Tymberlee Hill, Mark Saul, Joy Osmanski, Michael McGrady, Shelley Robertson, Cassandra Braden,

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